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Incluye artículos de investigación escritos por investigadores del Instituto y otras instituciones científicas y de educación superior, que hayan contado con los auspicios de INACH. En sus inicios estos trabajos fueron publicados en la serie Publicaciones Ocasionales y otras fuentes de información.
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Browsing Artículos by Subject "Antimicrobial"
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Item Antibacterial activity of the antarctic bacterium Janthinobacterium sp. SMN 33.6 against multi-resistant Gram-negative bacteria(Pontificia Universidad Católica de Valparaíso, 2014) Asencio, Geraldine; Lavin, Paris; Alegria, Karen; Domínguez, Mariana; Bello, Helia; González-Rocha, Gerardo; González-Aravena, MarceloBackground: The increment of resistant strains to commonly used antibiotics in clinical practices places in evidence the urgent need to search for newcompounds with antibacterial activity. The adaptations that Antarctic microorganisms have developed, due to the extreme environment that they inhabit, promote themas a potential new source of active compounds for the control of microorganisms causing infections associated with health care. The aimof this studywas to evaluate the antibacterial activity of an ethanol extract of the Antarctic bacterium Janthinobacterium sp., strain SMN 33.6, against nosocomial multi-resistant Gram-negative bacteria. Results: Inhibitory activity against human Gram-negative bacterial pathogens, with concentrations that varied between 0.5 and 16 μg ml-1, was demonstrated. Conclusions: The ethanolic extract of Janthinobacterium sp. SMN 33.6 possesses antibacterial activity against a chromosomal AmpC beta-lactamase-producing strain of Serratia marcescens, an extended-spectrum beta-lactamase-producing Escherichia coli and also against carbapenemase-producing strains of Acinetobacter baumannii and Pseudomonas aeruginosa. This becomes a potential and interesting biotechnological tool for the control of bacteria with multi-resistance to commonly used antibiotics.Item Pseudomonas and pedobacter isolates from King George Island inhibited the growth of foodborne pathogens(De Gruyter Open, 2011) Wong, Clemente Michael Vui Ling; Tam, Heng Keat; Alias, Siti Aisyah; González, Marcelo; González-Rocha, Gerardo; Domínguez-Yévenes, MarianaThis report describes the isolation and characterization of bacterial isolates that produce anti−microbial compounds from one of the South Shetland Islands, King George Is− land, Antarctica. Of a total 2465 bacterial isolates recovered from the soil samples, six (BG5, MTC3, WEK1, WEA1, MA2 and CG21) demonstrated inhibitory effects on the growth of one or more Gram−negative or Gram−positive indicator foodborne pathogens (i.e. Escherichia coli 0157:H7, Salmonella spp., Klebsiella pneumoniae, Enterobacter cloacae, Vibrio parahaemolyticus and Bacillus cereus). Upon examination of their 16S rRNA se− quences and biochemical profiles, the six Antarctic bacterial isolates were identified as Gram−negative Pedobacter cryoconitis (BG5), Pseudomonas migulae (WEK1), P. corru− gata (WEA1) and Pseudomonas spp. (MTC3, MA2, and CG21). While inhibitors produced by strains BG5, MTC3 and CG21 were sensitive to protease treatment, those produced by strains WEK1, WEA1, and MA2 were insensitive to catalase, lipase, −amylase, and prote− ase enzymes. In addtion, the six Antarctic bacterial isolates appeared to be resistant to multi− ple antibiotics.