Evolution in chronic cold: varied loss of cellular response to heat in antarctic notothenioid fish

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dc.contributor.authorBilyk, Kevin T.
dc.contributor.authorVargas-Chacoff, Luis
dc.contributor.authorCheng, Chi - Hing Christina
dc.date.accessioned2019-01-07T21:21:41Z
dc.date.available2019-01-07T21:21:41Z
dc.date.issued2018-09-19
dc.description.abstractBackground: Confined within the freezing Southern Ocean, the Antarctic notothenioids have evolved to become both cold adapted and cold specialized. A marked signature of cold specialization is an apparent loss of the cellular heat shock response (HSR). As the HSR has been examined in very few notothenioid species to-date, it remains unknown whether HSR loss pervades the Antarctic radiation, or whether the broader cellular responses to heat stress has sustained similar loss. Understanding the evolutionary status of these responses in this stenothermal taxon is crucial for evaluating its adaptive potential to ocean warming under climate change. Results: In this study, we used an acute heat stress protocol followed by RNA-Seq analyses to study the evolution of cellular-wide transcriptional responses to heat stress across three select notothenioid lineages - the basal temperate and nearest non-Antarctic sister species Eleginops maclovinus serving as ancestral proxy, the cryopelagic Pagothenia borchgrevinki and the icefish Chionodraco rastrospinosus representing cold-adapted red-blooded and hemoglobinless Antarctic notothenioids respectively. E maclovinus displayed robust cellular stress responses including the ER Unfolded Protein Response and the cytosolic HSR, cementing the HSR as a plesiomorphy that preceded Antarctic notothenioid radiation. While the transcriptional response to heat stress was minimal in P. borchgrevinki, C rastrospinosus exhibited robust responses in the broader cellular networks especially in inflammatory responses despite lacking the classic HSR and UPR. Conclusion: The disparate patterns observed in these two archetypal Antarctic species indicate the evolutionary status in cellular ability to mitigate acute heat stress varies even among Antarctic lineages, which may affect their adaptive potential in coping with a warming world.es_ES
dc.description.sponsorshipThis work was funded by the US National Science Foundation Division of Polar Programs grant ANT-1142158 to C-HC Cheng and AL DeVries. Additional support for KT Bilyk came from the US National Science Foundation Division of Polar Programs grant ANT-1341701 to KT Bilyk and C-HC Cheng. L Vargas-Chacoff was supported by Fondap-IDEAL 15150003. The funding agencies of this study play no role in the design, collection, analysis, and interpretation of data and writing of this manuscript.es_ES
dc.identifier.citationBMC Evolutionary Biology (2018) 18:143es_ES
dc.identifier.issn1471-2148
dc.identifier.otherDOI: 10.1186/s12862-018-1254-6
dc.identifier.urihttp://hdl.handle.net/20.500.11894/1220
dc.language.isoenes_ES
dc.publisherBMC Campuses_ES
dc.relation.ispartofBMC Evolutionary Biologyes_ES
dc.relation.ispartofVol. 18:143
dc.rightsCreative Commons Attribution 4.0 International licensees_ES
dc.subjectCienciaes_ES
dc.subjectUnfolded protein responsees_ES
dc.subjectAntarctic fishes_ES
dc.subjectCellular stress responsees_ES
dc.subjectStenothermales_ES
dc.titleEvolution in chronic cold: varied loss of cellular response to heat in antarctic notothenioid fishes_ES
dc.typeArtículoes_ES

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